Epilepsy Surgery Research

NeurosurgeryOne is committed to providing all patients with evidence-based medical treatments. Information on our epilepsy pages comes from the studies listed below. 


Englot DJ, Ouyang D, Garcia PA, Barbaro NM, Chang EF. Epilepsy surgery trends in the United States, 1990-2008. Neurology. 2012;78(16):1200-1206. https://doi.org/10.1212/WNL.0b013e318250d7ea

Engel J Jr, McDermott MP, Wiebe S, et al. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. The Journal of American Medical Association. 2012 Mar 7;307(9):922-30. https://doi.org/10.1001/jama.2012.220 

Simasathien T, Vadera S, Najm I, et al. Improved outcomes with earlier surgery for intractable frontal lobe epilepsy. Annals of Neurology. 2013 May;73(5):646-54. https://doi.org/10.1002/ana.23862

Taft C, Sager Magnusson E, Ekstedt G, Malmgren K. Health-related quality of life, mood, and patient satisfaction after epilepsy surgery in Sweden—a prospective controlled observational study. Epilepsia. 2014;55(6):878-885. https://doi.org/10.1111/epi.12616

Neal EG, Maciver S, Schoenberg MR, Vale FL. Surgical disconnection of epilepsy network correlates with improved outcomes. Seizure. 2020;76:56-63. https://doi.org/10.1016/j.seizure.2020.01.018

Epilepsy Foundation. Risks and Benefits. (2020, April 2). https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/surgery/risks-and-benefits

Devinsky O, Barr WB, Vickrey BG, et al. Changes in depression and anxiety after resective surgery for epilepsy. Neurology. 2005 Dec 13;65(11):1744-9. https://doi.org/10.1212/01.wnl.0000187114.71524.c

Zarroli K, Tracy JI, Nei M, et al. Employment after anterior temporal lobectomy. Epilepsia. 2011 May;52(5):925-31. https://doi.org/10.1111/j.1528-1167.2011.03098.x

Dawkins RL, Omar NB, Agee BS, et al. Assessment of driving outcomes after epilepsy surgery. Epilepsy & Behavior. 2015 Nov;52(Pt A):25-30. https://doi.org/10.1016/j.yebeh.2015.08.035

Schiltz NK, Kaiboriboon K, Koroukian SM, et al. Long-term reduction of health care costs and utilization after epilepsy surgery. Epilepsia. 2016 Feb;57(2):316-24. https://doi.org/10.1111/epi.13280

Engel J, Jr., Wiebe S, French J, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology. 2003;60(4):538-547. https://doi.org/10.1046/j.1528-1157.2003.48202.x

Wiebe S, Blume WT, Girvin JP, Eliasziw M, et al. Effectiveness, Efficiency of Surgery for Temporal Lobe Epilepsy Study G. A randomized, controlled trial of surgery for temporal-lobe epilepsy. New England Journal of Medicine. 2001;345(5):311-318. https://doi.org/10.1056/NEJM200108023450501

Kang JY, Wu C, Tracy J, et al. Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia. 2016 Feb;57(2):325-34. https://doi.org/10.1111/epi.13284

Bergey, GK, Morrell, MJ, Mizrahi, EM, et al. Long-term Treatment With Responsive Brain Stimulation in Adults With Refractory Partial Seizures. Neurology. 2015;84(8):810-7. https://doi.org/10.1212/wnl.0000000000001280 

Englot DJ, Rolston JD, Wright CW, Hassnain KH, Change EF. Rates and Predictions of Seizure Freedom with Vagus Nerve Stimulation for Intractable Epilepsy. Neurology. 2016;79(3):345-353. https://doi.org/10.1227/NEU.0000000000001165